When you are running a VB express 2008 on a 64 bit operating system there are times you need to compile the app as a 32bit. One example is if you need to open an access database. There is not a 64 bit version of jet. To force your app to use the 32 bit version you need to compile the app for the x86 version of the framework.
Unfortunately there is no built in way to change the target cpu in VB express 2008. Your best bet is get a copy of Visual studio but if this is not...